Why is the combination of 2% chlorhexidine gluconate (CHG) and 70% isopropyl alcohol (IPA) better than IPA alone?
A. The combination of fast-acting and long-lasting antimicrobial activity is the key to an effective skin antiseptic. IPA alone provides a 99.99% reduction in bacteria, but it does not provide long-lasting microbial kill. CHG maintains antimicrobial activity, demonstrating 2 log10 and 3 log10 for at least 48 hours1,2 compared to two hours for free iodine.3 Because ChloraPrep contains the combination of isopropyl alcohol and chlorhexidine, it is superior to isopropyl alcohol alone.
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