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Why is the A260/280 ratio of my oligo less than 1.8?

a260 oligo ratio
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Why is the A260/280 ratio of my oligo less than 1.8?

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As illustrated in the table below, the base composition of the oligonucleotide determines the A260/280 ratio. Thus, the A260/280 ratio is not an accurate measurement of oligonucleotide quality and if your ratio is less than 1.8 it may be due to the base composition of the oligo.

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