Why is so much DNA needed? Can smaller amounts be accepted?
The genotyping is carried out on high density arrays that type approximately 500,000 SNPs on each sample. To be successful, the process requires a quantity of DNA that gives a high call rate (~99%). Inadequate amounts of DNA leads to the loss of too much data and may cause the entire array to give unusable data for that sample. It is better to err on the side of too much DNA than too little.
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