Why is it important to test the 2009 H1N1 influenza vaccine in HIV-infected children, youth and pregnant women?
It is important to test the 2009 H1N1 influenza vaccine in HIV-infected populations, particularly children, youth and pregnant women, because HIV infection and pregnancy both increase the risk for a poor immune response to the normal 15-microgram dose of seasonal influenza vaccine given to the general population. In addition, children, young people and pregnant women are at higher risk for more severe illness from the 2009 H1N1 influenza virus than other groups, and HIV-infected individuals in these populations may be particularly vulnerable. Because of the increased vulnerability of these populations, these trials are testing whether doses of licensed 2009 H1N1 influenza vaccine that are higher than doses being tested in other groups can safely elicit protective immune responses in HIV-infected children, youth and pregnant women. • Who will participate in these 2009 H1N1 influenza vaccine clinical trials? One trial will enroll 130 HIV-infected pregnant women ages 18 to 39 years who ar
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- Why is it important to test the 2009 H1N1 influenza vaccine in HIV-infected children, youth and pregnant women?
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