Why is extra progesterone often prescribed for immune Tx?
Ladies with autoimmune issues (often signalled by elevated populations of CD19+5+ cells in the blood) may have anti-progesterone antibody activity and therefore need extra progesterone supplementation to ensure that the their blood levels are high and steady enough to maintain a pregnancy until 12-16 weeks. Progesterone also has anti-inflammatory properties which may also be helpful due to the higher levels of inflammation experienced by ladies with both autoimmune and alloimmune (DQa match) issues. Extra progesterone will not reduce a high CD19+5+ level, but is given as a precaution against one of the consequences of a high CD19+5+ (the primary treatments to try to bring excessive CD19+5+ down are steroids and IVIG (and possibly intralipids).
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