Why is elevated cholesterol a concern for people with HIV?
The concern was that we were making people healthier from an HIV standpoint, but we were creating new problems by putting people at risk for cardiovascular disease. Additionally, elevated triglycerides can cause pancreatitis, a painful inflammation of the pancreas. Why did you conduct this study? There is a reasonable amount of information about people before and after they start these highly active HIV medicines. But the MACS study has a lot of information about individuals who came into the study HIV-negative and then acquired HIV infection during the course of the study. We realized that this group provided a unique opportunity to try to establish lipid changes before and after infection, in addition to before and after starting HIV therapy. It’s been known for quite a long time that people with HIV have a drop in cholesterol soon after becoming infected, so looking at levels before and after starting HAART, but not at the levels before they were infected with HIV, may not really gi
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