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Why is Avian Flu so different from other influenza viruses that affect humans?

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Why is Avian Flu so different from other influenza viruses that affect humans?

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Historically, when a virus that primarily infects animals has a genetic change that enables it to infect humans, it causes more problems than the usual strains of influenza virus that infect humans. This is because there is no natural immunity among the human population.

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