Why is a reaction written in one direction even if the opposite direction is the one observed in vivo?
All reactions within a given sub-subclass are written in the same direction irrespective of the direction in which the reaction normally occurs in vitro/vivo. Many factors can influence the direction in which a reaction occurs so, by using the same direction for all reactions within a sub-subclass, we are not making any assumptions about the equilibrium of the reaction or its direction in vivo.
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