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Why has the Supplemental Guidance been issued separately rather than included in the final Guidelines?

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Why has the Supplemental Guidance been issued separately rather than included in the final Guidelines?

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The Supplemental Guidance focuses on assessing the effects of early lifestage exposure and includes a review of existing scientific literature on chemical effects in animals and human exposure. Because the areas of carcinogenicity, genesis of disease, and effects on susceptible life stages and populations are constantly and quickly evolving, the EPA expects that this will be the first of several supplemental guidance documents to the Guidelines. These companion documents will provide additional information on how to address certain aspects of children’s risk to the cancer causing effects of some chemicals.

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