Why has it taken so long for any studies to be carried out on Alkaptonuria and its degenerative nature? Does anyone else suffer with eczema on their joints, especially back of knees?
There are several reasons contributing to the rarity of research carried out on Alkaptonuria. It is a rare disease with an incidence of 1 in 250,000 to 1 in 1,000,000. Many physicians will never see a patient with alkaptonuria in their career. The rarity also makes it difficult to obtain a large enough number of patients to carry out controlled studies. Lack of funding for rare diseases is another factor.
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