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Why doesn the non-target control vector affect gene expression?

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Why doesn the non-target control vector affect gene expression?

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The non-target control vector (Product Nos. SHC002, SHC002V) has at least 5 bp mismatches within the shRNA to any known human or mouse genes, limiting its ability to target any human or mouse genes. Please refer to the product listing for hairpin sequence and vector map.

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