Why doesn an immune system attack cancer cells?
Most, if not all, cancer or tumor cells have self-recognition “passwords” that not only pass the antigen screening process but also interfere with the antigen comparison processes and hide their antigens. Thus, cancer cells’ genetic mutation information in antigens is not recognized by the immune system. The solid structure of the tumor also traps immune components including macrophages. The self-recognition “passwords” are self-recognition molecular patterns including MHC I and MHC II. Cancer cells with expression or over-expression of MHC I can grow at the originating place to usually form a tumor. Cancer cells expressing or over-expressing MHC II can travel around the body for metastasis. Blood cancer is a metastatic cancer but may not form local tumors if they do not express MHC I. In order for a body’s immune system to recognize cancer cells, the immune system needs to be genetically engineered or re-built with CancerVaccineâ„¢ so the immune system’s detection method and sensitivity