Why does Uremia cause fibrinous pericarditis?
Uremic pericarditis is thought to result from inflammation of the visceral and parietal layers of the pericardium by metabolic toxins that accumulate in the body owing to kidney failure. Other factors may be involved, however, because pericarditis also may occur in patients with chronic renal failure who already are receiving dialysis therapy. Renal failure(uremia) accounts for approximately 12% of cases. In the predialysis era, pericarditis developed in 35-50% of patients with uremia who had chronic renal failure and less commonly in those with acute renal failure. Death often followed in several weeks. With dialysis, the incidence rate is less than 10%. Pericarditis occurs after the onset of dialysis in 8-12% of cases. ECG commonly does not show the typical ST-T segment changes due to lack of inflammation. In uremic patients, heart rates may be deceptively slow with tamponade, fever, and hypotension due to autonomic impairment. Some authors suggest that uremic pericarditis is a diffe
