Why does treatment with a common antibiotic (Biaxin™) dramatically improve asthma in some patients?
Background: Some recent research has suggested that one of two bacteria, Mycoplasma or Chlamydia pneumoniae, are found in the airways of approximately 50% of asthmatic patients. These bacteria are common causes of bronchitis and pneumonia but were not previously thought to cause chronic infections or to make asthma worse. Further research has also shown that treatment with a macrolide antibiotic like Biaxin™ can improve asthma, especially in patients with evidence of infection with either Mycoplasma or Chlamydia pneumoniae. Purpose: To compare the effects of treatment with Biaxin™ versus placebo in two groups of asthmatics, one with evidence of Mycoplasma or Chlamydia pneumoniae and one without. Study design: This 32-week, placebo-controlled study examines the effect of treatment with Biaxin™ on asthma symptoms in participants whose asthma is not completely controlled when taking a low dose of inhaled corticosteroid (Flovent™). Individuals aged 18-60 years who meet lung function and ot
