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Why does the numerator of the Cockroft creatinine clearance formula represent the creatininuria of 1000 min?

April 26, 2017clearance Creatinine Formula min numerator

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Why does the numerator of the Cockroft creatinine clearance formula represent the creatininuria of 1000 min?

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To understand this it is best to briefly recall the work of Cockroft and Gault. First they established the regression of creatininuria per kilogram in relation to age in 296 males whose duplicate measurements of 24-h creatininuria gave similar results.