Why does the combination of Dolorex and an alpha2 agonist have to be used with caution in animals with heart disease?
Dolorex potentially produces cardiovascular and respiratory depression. Alpha2 agonists produce pronounced cardiovascular and respiratory depression. These effects will be increased when the two agents are used in combination. Animals with heart disease already have a relative cardiovascular system depression. In these animals, if neuroleptanalgesia is required the concurrent use of anticholinergic drugs, e.g atropine should be considered. This will help to ensure that the heart rate is maintained in these animals.
