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Why does neostigmine augment the depolarizing response of succinylcholine?

April 26, 2017augment neostigmine Response succinylcholine

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Why does neostigmine augment the depolarizing response of succinylcholine?

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Neostigmine will potentiate (worsen it) the block of the depolarizing (non-competitive) NMJ blocker succinylcholine. Succinylcholine acts like a long lasting Ach. The membrane is depolarized and remains depolarized in Phase 1 block. Increasing the Ach concentration further will only make the block longer and deeper.