Why does lithium toxicity worsen by sodium depletion (e.g., by thiazide diuretics)?
Why does lithium toxicity worsen by sodium depletion (e.g., by thiazide)? As lithium is closely related to sodium in its properties it should also excrete, like sodium, by thiazide diuretics but can anyone tell me why always the reverse is occurred? ….renal clearance of lithium is reduced about 25% by diuretics e.g., thiazide diuretics Reply With Quote 6th, July 2009 10:19 AM #2 Nikolai View Profile View Forum Posts View Blog Entries View Articles Keep it surreal Join Date Sep 2008 Location West Midlands Posts 1,161 Re: Why does lithium toxicity worsen by sodium depletion (e.g., by thiazide diuretics Li+ and Na+ are similarly shaped ions, so if Na+ levels drop, the body (wrongly assuming they are the same) compensates by increasing the reabsorption of Li+ at the proximal tubule in the nephron. Diuretics acting distal to the proximal tubule (i.e at the distal tubule) also have this effect. http://i620.photobucket.com/albums/t…snroses2-1.jpg We are real. We are not glam sh*t or anyth
