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Why does libSlice sometimes calculate a different consensus than TA & TED would have?

April 26, 2017CALCULATE consensus different libslice TA ted

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Why does libSlice sometimes calculate a different consensus than TA & TED would have?

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libSlice uses an updated method for determining the consensus of a slice and fully utilizes the quality value information given. The method used by TA & TED is more sensitive to the number of reads supporting a base than the quality values of the bases. The consensus as calculated by libSlice generally be in the sense that it is defined using a well defined and understood method.