Why does LC Laboratories use those flame-sealed, snap-off glass ampules for packaging most of its products, rather than the easier-to-use serum bottles with rubber lined aluminum closures?
A. We realize that the serum bottles with rubber closures are easier to use for many people. However, for several reasons, they are definitely inferior to our ampules from the standpoint of product purity and stability. The rubber seals on serum bottles are not entirely airtight. Thus, even in the freezer, many important products turn out to be unstable during extended storage in serum bottles because oxygen and moisture can enter and cause degradation. We know from experience that this degradation will occur with phorbol esters and many other organic compounds. In order to provide products that will maintain high purity while in our inventory (and in our customers’ freezers after shipment), we believe the flame-sealed ampules are best. Our ampules are made of highly inert, Type I borosilicate glass and are sealed under a nitrogen or argon atmosphere, assuring maximal long-term stability and purity. For example, we have observed degradation of phorbols in less than a year when stored i
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