Why does HLA-B27 predispose to autoimmune Spondyloarthritis?
Add to your list(s) Download to your calendar using vCal • Dr Paul Bowness, MRC Human Immunology Unit, Institute of Molecular Medicine, University of Oxford • Wednesday 20 May 2009, 12:30-13:30 • Lecture Theatre, Department of Pathology, Tennis Court Road. If you have a question about this talk, please contact Prof. Jim Kaufman. Host: John Trowsdale (jt233@cam.ac.uk) Paul Bowness studies the role of the Human Leukocyte Antigen (HLA) class I allele HLA B27 in the pathogenesis of spondyloarthritis. HLA B27 forms a complex with beta 2 microglobulin (ß2m) and binds antigenic peptides within cells. These complexes then travel to the cell surface where they can be recognised by cytotoxic T lymphocytes which then kill the infected cell. Despite extensive studies, the pathogenic role of HLA B27 remains unknown. The role of HLA B27 in spondyloarthropathy might stem from its function in antigen presentation, either in peptide selection or other aspects of its cell biology, for example its propen
