Why Does Familial Shar-Pei Fever predispose these dogs to Amyloidosis?
Dogs with FSF have chronically elevated levels of the chemicals that raise the levels of the APP – even when they are not having fevers. If the dog’s body is overwhelmed by too much APP or there is a problem with the elimination process, amyloidosis occurs. Why do some Shar-Pei with FSF get Amyloidosis and others do not? • We are speculating that it is probably due to variables in the degree of APP in the dog’s bloodstream – some dogs may have mild levels and others severely elevated amounts which may overwhelm their ability to eliminate them entirely. In humans with periodic fever disorders, it is believed that there may be a linked mutation that prevents the normal elimination of the by-products the APP leading to amyloidosis in some patients. I suspect both factors are important in the development of amyloidosis in Shar-Pei. • FSF and Amyloidosis are closely linked and FSF is a huge risk factor for developing Amyloidosis. However, not every Shar-Pei with recurrent fevers from FSF wi
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