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Why does clonazepam in urine screen negative for benzodiazepines, yet confirm positive?

April 26, 2017BENZODIAZEPINES clonazepam confirm negative positive screen urine

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Why does clonazepam in urine screen negative for benzodiazepines, yet confirm positive?

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Clonazepam is present as a metabolite in urine. It does not react well by the commercially- available screening reagents. It is not recognized well by the benzodiazepine antibody. Therefore, clonazepam metabolite is quantitated separately by LC/MS/MS to assure that it is detected at a very small concentration.