Why does blood clot in the arteries of people with coronary heart disease and at risks of strokes?
People with coronary artery disease develop a build up fatty plaque (atheroma) in the arteries. Over time platelets aggregate to form thrombi,- part of the plaque can rupture and a blood clot may form at the site of the rupture and block an artery supplying blood to the heart (heart attack) or the brain (stroke).