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Why do you not get tachycardia with the alpha-1 selective blockers: ie. prazosin and terazosin?

April 26, 2017alpha-1 blockers prazosin selective tachycardia terazosin

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Why do you not get tachycardia with the alpha-1 selective blockers: ie. prazosin and terazosin?

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Phentolamine (non-selective, alpha1- and alpha2-blocker) causes a fall in BP with refex tachycardia. Whereas Prazosin and Terazosin are selective alpha1-blockers. It is thought that since they leave the presynaptic alpha2-receptors operational, this prevents the reflex tachycardia.