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Why do the results differ when multiple dockings are done with the same input?

differ dockings input results
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Why do the results differ when multiple dockings are done with the same input?

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Multiple docking calculations are specified in a docking parameter file using one of the following keywords: ‘ga_run’, ‘do_local_only’ or ‘runs’ plus ‘simanneal’. In general, the results will differ between dockings when using the same input.

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