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Why do the directions say to only apply LATISSETM solution to the base of the upper eyelashes?

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Why do the directions say to only apply LATISSETM solution to the base of the upper eyelashes?

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A clinical trial of LATISSETM was conducted on patients who applied the product to the base of their upper lashes only. Applied nightly, the transfer of LATISSETM solution from the upper to lower eyelid may occur naturally because the eyelids are closed and the eyelashes touch each other. Over application may increase the chance of experiencing side effects. To ensure safety and maximize effectiveness, please follow the directions provided.

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