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Why do the directions say to only apply LATISSE solution to the base of the upper eyelashes?

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Why do the directions say to only apply LATISSE solution to the base of the upper eyelashes?

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A clinical trial of LATISSE was conducted on patients who applied the product to the base of their upper lashes only. Do not apply in your eye or to the lower lid. There is the potential for hair growth to occur in areas where LATISSE solution comes in repeated contact with the skin surface. It is important to apply LATISSE only to the skin of the upper eyelid margin at the base of the eyelashes using the accompanying sterile applicators, and to carefully blot any excess LATISSE from the eyelid margin to avoid it running onto the cheek or other skin areas.

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Latisse is FDA approved for use on the upper lashes. Applying Latisse to the lower lashes is not recommeded by experts.

Since there is too much risk of corneal damage/abrasion and infection that can occur during the application process at lower eyelashes.  Also applying Latisse  to the upper lash application does help the lower lashes and minimizes risks of side effects.

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A clinical trial of LATISSE was conducted on patients who applied the product to the base of their upper lashes only. Applied nightly, the transfer of LATISSE solution from the upper to lower eyelid may occur naturally because the eyelids are closed and the eyelashes touch each other. Over application may increase the chance of experiencing side effects. To ensure safety and maximize effectiveness, please follow the directions provided.

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