Why do the directions on the ChloraPrep label indicate that it should be applied in a back-and-forth direction?
A. Clinical testing has shown that the back-and-forth motion used to apply ChloraPrep supports the efficacy of the solution. Because 80% of transient skin flora resides in the first five cell layers of skin11, it is important to reach those lower layers and kill the bacteria dwelling further down. The skin contains many cracks and crevices where harmful bacteria reside. The back-and-forth action creates friction and helps drive the solution into crevices and lower layers, reaching more bacteria. Further, there is no published data to support the concentric circular application methodology. The New Drug Application (NDA) approved by the FDA for ChloraPrep included in vivo studies which showed that a minimum 3 log10 reduction for 48 hours was achieved on moist sites, and a 2 log10 reduction for 24 hours was achieved on dry sites while using a friction (back-and-forth) scrub.
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