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Why do some vaccines require boosters (subsequent shots) and how is it determined how much time should pass between an initial vaccine and a booster?

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Why do some vaccines require boosters (subsequent shots) and how is it determined how much time should pass between an initial vaccine and a booster?

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All of that is empirical: they are tested initially in various ways and their efficacy determined. In general we try to keep it as simple as possible, so most people will comply, even if another shot might add some protection.

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