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Why do some dogs and cats with end-stage renal disease test negative for protein on the Urine P:C Ratio or have a result that actually decreases over time?

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Why do some dogs and cats with end-stage renal disease test negative for protein on the Urine P:C Ratio or have a result that actually decreases over time?

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Dogs and cats with end-stage renal disease can potentially have a negative result with the Urine P:C Ratio. As the number of functional nephrons (the functional units of the kidney) decline, proteinuria may decrease or become negative. It is not uncommon to find a decreasing trend in the magnitude of Urine P:C Ratio as renal disease progresses to a terminal state.

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