Important Notice: Our web hosting provider recently started charging us for additional visits, which was unexpected. In response, we're seeking donations. Depending on the situation, we may explore different monetization options for our Community and Expert Contributors. It's crucial to provide more returns for their expertise and offer more Expert Validated Answers or AI Validated Answers. Learn more about our hosting issue here.

Why do some dbVar variants have >1 location?

dbvar location variants
0
Posted

Why do some dbVar variants have >1 location?

0

There are two reasons: When a submitter gives us data on an assembly obtained from UCSC, we translate this into native assembly coordinates and map sequences (chromosomes and unplaced/unlocalized sequences) to their accession.versions. UCSC concatenates unplaced/unlocalized sequences into pseudo-scaffold objects they call chr*_random. In some cases, submitters have provided data that cross gaps on the ‘chr*_random’ sequences, meaning that the feature actually maps to two different, unrelated sequences. More than one location may also be provided if the variant is the result of a transposition event. In this case, coordinates from both the donor and recipient sites are provided, to retain as much information about the variant event as possible.

What is your question?

*Sadly, we had to bring back ads too. Hopefully more targeted.

Experts123