why do researchers think X-linked CGD carriers get lupus?
A. We don’t know exactly but we believe that this due indirectly to the lyonisation process. We know that the neutrophils that carry the genetic mistake in CGD do not appear to die as quickly “normal” cells and these abnormal cells also don’t clear up other dead cells as well as they should. Thus, there are extra dead cells in tissues that could set up an inflammatory response and generate abnormal responses in the body that show up as symptoms of SLE. There are likely to be other modifier factors that also influence how badly someone will be affected. Q. Does this mean that all X-Linked carriers get lupus? A. No, some carriers will not develop any of the lupus-like symptoms we have described. Of the 19 carriers in our study 3 had no symptoms of lupus and were considered free from this condition. Two others suffered only from acne. Q. Was there any relationship between the percentage of phagocytes not working properly in carriers of X-linked CGD and the symptoms of lupus? A. No there w
