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Why do I get positive buprenorphine screens that do not confirm?

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Why do I get positive buprenorphine screens that do not confirm?

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There is not a definitive answer for this. The buprenorphine antibodies in the screening reagent are very sensitive and may detect metabolic products or large concentrations of other drugs that cause the chemistry to give a positive screen. Yet the target drug and its primary metabolite are not actually present at sufficient concentration to be above the confirmation cutoff value.

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