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Why do eligible interventions have to be implemented and evaluated in a minimum of three different sites?

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Why do eligible interventions have to be implemented and evaluated in a minimum of three different sites?

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The intervention must be implemented and evaluated in at least three distinct sites to allow assessment of replicability. We are interested in how generalizable the interventions are as well as how they might need to be tailored for different settings to be most effective. Our goal is to study intervention implementation in sites that, when compared to each other, provide unique administrative structures, target populations, geographic regions or patient care systems.

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