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Why did they think estrogen plus progestin would prevent cognitive decline and dementia?

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Why did they think estrogen plus progestin would prevent cognitive decline and dementia?

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Research in tissue culture cells and in animals has shown that estrogen has a number of beneficial effects on the brain. Some studies observing certain groups of women for several years suggested that those women using menopausal hormone therapy kept their memory and thinking abilities longer than those not on such treatment.

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