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Why citric acid cycle is oxygen dependent?

April 26, 2017acid citric CYCLE dependent oxygen

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Why citric acid cycle is oxygen dependent?

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The citric acid cycle does not directly utilize oxygen, however it is still necessary in order for it to proceed. The reason for this is that in order for NADH to be reduced back into NAD+, oxygen must be present. If NAD+ is not regenerated, the cycle can’t proceed, thus fermentation evolved.