Why choose a Wnt protein considering its alternative roles in other pathways?
We chose it because we found that in previous studies, to our surprise, some T-Lymphocytes progenitors were present in lymph nodes that do not produce T-Lymphocytes. We found that the T-cell progenitors that were present normally did not expand in the lymph and underwent apoptosis. We concluded that there must be a factor that enhances the survival of T-cell progenitors that is present in the thymus but absent in the lymph node. And that this factor would be responsible for the fact that T-cell progenitors do generate T-Lymphocytes in thymus and not in lymph nodes. Listen to the audio clip the end of the article to hear Dr. Perreault explain how gene expression profiling was used in his research. What were your findings and can you place them in a broader immunologic context? In the first experiment we injected a foetal liver cell transduced with Wnt4 into irradiated recipients and we waited for sixteen weeks. Then studied the hematopoietic organs and the lymphoid organs of recipients.
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