Why can the elimination rate (or half-life) be different following oral dosing and intravenous dosing?
A. Because the plasma concentration-time curve can be controlled by different processes in the long-time limit. Essentially, the decay of the plasma concentration-time curve is controlled by the slowest process in the system. If oral absorption is slower than clearance from the somatic model, absorption is the rate-limiting step – but this can only be observed when we simulate oral dosing.
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