Why can Dolorex not be administered with other opioids?
It is important to recognize that Dolorex has both agonist and antagonist actions. Opioids work at a number of different types of receptor. Dolorex is an agonist at kappa and an antagonist at mu receptors. This means that Dolorex can remove the analgesic effect in animals that have already received pure opioid mu agonists (such as morphine). This is why Dolorex should not be administered along with another opioid agonist. Combination of Dolorex with another opioid is also likely to increase the chance of and severity of any side effects.
