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Why are the three reports described in the Annals of Internal Medicine significant?

April 26, 2017annals Internal Medicine reports SIGNIFICANT

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Why are the three reports described in the Annals of Internal Medicine significant?

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These reports are significant due to the serious nature of the adverse events. All three patients had jaundice and abnormal liver function. One patient recovered, one required a transplant, and one died. All three patients had previously been healthy.