Why are the drugs of common cold shouldn given with MAO inhibitors?
These agents contain indirect-acting symapathomimetics e.g. phenylpropanolamine and pseudoephedrine which release norepinephrine from the sympathetic nerve endings. If MAO enzyme is inhibited; norepinephrine will not be metabolized leading to hypertensive crisis Q2: I want to know why you ,DR, choosed in your wonderful short Q about A.N.S clonidine for the ttt of noctournal diarrhea in DM as it is alpha 2 agonist and considered aldomet is C.I in this case as it induce diarrhea although it is also alpha 2 agonist and some books wrote that it induce dry mouth and constipation due to this effect (alpha 2 agonist) A:Alpha methyl dopa acts mainly centrally leading to inhibition of the sympathetic outflow which makes the parasympathetic dominant (this leads to diarrhea). Clonidine acts not only centrally but also on alpha-2 receptors on the nerve endings of the parasympathetic vagal fibers of the intestine leading to decrease Ach release (anti-diarrhoeal action).
