Why are some gene products annotated to both a parent term and a child term?
Question: I was wondering why some gene products in the gene_product table are assigned to terms that are a parent or grand-parent etc … of another term that has been assigned to the gene product. For example, why is “protein kinase activity” assigned to the gene product with symbol KFMS_HUMAN if “protein tyrosine kinase activity” was already assiged to this gene? This is done when there is explicit evidence to support separate annotations; usually it means that there is strong evidence for a more general annotation (parent term) and weaker evidence supporting a more specific annotation (child term). From the GO annotation guide: Uncertain knowledge of where a gene product operates should be denoted by annotating it to two nodes, one of which can be a parent of the other. For instance, a yeast gene product known to be in the nucleolus, but also experimentally observed in the nucleus generally, can be annotated to both nucleolus and nucleus in the cell component ontology. Even though
