Why are some exons designated with a letter (ie. 10a) which is denoted clearly in the exon-map display?
This annotation is used by NCBI to distinguish between exons that are differentially spliced at the 5′ or 3′ boundaries of the exon sequence. For example, exons 10a and 10b share the same sequence information derived from the genomic region but utilize different alternative splice sites, which results in sequence differences at the exon boundaries in the mature mRNA. This is an important consideration when selecting exons from the exon-exon map display for primer design.
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