Why are membrane permeability and protein binding important parameters?
Membrane permeability affects drug absorption and protein binding affects its distribution in the body. Hence, both parameters are key indicators for bioavailability of drug candidates in the developmental pipeline. For effective and efficient drug development pharmacokinetic properties, drugs safety and efficacy need to be optimized at the same time. The products and services performed by Sovicell determine the pharmacokinetic parameters and distinguish potential safety problems before entering into a clinical trial. Membrane affinity describes a small molecules’ ability to permeate through lipid membranes. Therefore it is directly related to the permeation rate across membranes such as the intestinal membrane or the blood brain barrier. Total intestinal absorption depends not only on permeability across the intestinal epithelium, but also on the drug’s pH dependent solubility in the intestine and the passage time. Equilibrium distribution of drugs between blood and brain depend not o
