Why are BOTH zidovudine (AZT) and lamivudine (3TC) recommended after HIV exposures?
As more people with HIV use zidovudine, more HIV becomes resistant to it. Using both drugs increases the chance that at least one will be active against the HIV strains involved in the occupational exposure. When given together to HIV-infected patients, zidovudine and lamivudine work well together for several months, even when the virus at first was zidovudine resistant.
