Why are antiphospholipid antibodies important?
The presence of both the lupus anticoagulant and anticardiolipin antibody is increased in lupus patients who have had thrombotic (blood clotting) complications such as deep venous thrombosis (“thrombophlebitis”), stroke, gangrene, and heart attack. Studies suggest that the presence of these antibodies may also increase the future risk of thrombotic events. Anticardiolipin antibody has been found to be increased in pregnant women with lupus who have had miscarriages. The combination of thrombotic problems, miscarriages, and a low platelet count has been called the “Antiphospholipid Antibody Syndrome.” It is not necessary to have lupus to have the Antiphospholipid Antibody Syndrome. It is important for doctors to realize this and to check people who have had a stroke, heart attack, or miscarriage for no known reason to see if they have these antibodies. Antiphospholipid antibodies interfere with the normal function of blood vessels, both by causing narrowing and irregularity of the vesse
