Who should not take estradiol?
Do not buy or take estradiol without first talking to your doctor if you have a circulation, bleeding, or blood-clotting disorder; undiagnosed, abnormal vaginal bleeding; or any type of breast, uterine, or hormone-dependent cancer. Taking estradiol may not be recommended in some cases if you have any of the conditions listed above. Before taking estradiol, tell your doctor if you have high blood pressure, angina, or heart disease; a history of stroke or heart attack; high levels of cholesterol or triglycerides in the blood; liver disease; kidney disease; asthma; epilepsy; migraines; diabetes; depression; gallbladder disease; uterine fibroids; or had a hysterectomy (uterus removed). You may not be able to take estradiol, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. The Women’s Health Initiative Memory Study (WHIMS) found that postmenopausal women 65 years of age or older who were treated with oral conjugate
