Who Should Be Treated with Antivirals?
• Treatment is recommended for both adults and children with influenza virus infection meeting the following criteria: • Persons with laboratory-confirmed or highly suspected influenza virus infection at high risk of complications (see Table 5 in the original guideline document) within 48 hours of symptom onset. Benefits have been best evaluated mostly among otherwise healthy adults with uncomplicated influenza with treatment initiated within 48 hours of symptom onset, although smaller numbers of persons with conditions increasing the risk of influenza complications have also been included in trials. Fewer data are available by which to make recommendations on treating persons 48 hours after symptom onset. Treatment is recommended regardless of influenza vaccination status, and regardless of severity of illness (A-II). • Persons requiring hospitalization for laboratory confirmed or highly suspected influenza illness, regardless of underlying illness or influenza vaccination status, if
