Who Is Affected and Where Are the Maxillofacial Lesions?
Maxillofacial osteonecrosis has been microscopically confirmed in patients as young as 14 years of age and as old as 94, and has been reported in both genders.44,59 Typically, however, three-fourths of patients are 35-64 years of age and three-fourths are women. Outside of the jaws, the head of the femur is the most common site of involvement, but any bone may be affected (Appendix B). Alveolar bone sites most often involved, in decreasing order of frequency, are the mandibular molar/retromolar areas, the maxillary molar/tuberosity areas, and the maxillary cuspid/lateral incisor areas (Table 4). Third molar sites account for 45% of all jawbone involvement. Most M-ON sites are old extraction sites, but another common presentation is a radiographically successful endodontic procedure which continues to be painful after therapy, even after extraction. Table 4: Location of 2,301 NICO lesions as reported on biopsy request forms from 1,333 patients with facial pain. Numbers represent the pro
